. 2017 Nov 16;36(1):41–49. doi: 10.5534/wjmh.17028

Table 1. Changes in physical and biochemical parameters following treatment of mice with udenafil and/or leptin for 9 days.

		Control diet				High-fat diet
	Udenafil	−	−	+	+	−	−	+	+
	Leptin	−	+	−	+	−	+	−	+
Body weight (g)		32.4±1.17	32.4±0.86	32.4±0.84	32.4±0.62	36.9±0.98^*	36.9±1.01	36.9±0.83	36.9±0.80
Initial
Final		31.4±1.13	29.8±0.65	30.0±0.78	29.3±0.82	36.1±0.83	35.4±1.01	33.1±0.92	32.6±0.54
Difference		1.1±0.30^a	2.6±1.22^a,b	2.4±0.44^a,b	3.1±0.86^b	0.9±0.26^a	1.5±0.27^a	3.8±0.41^b	4.3±0.42^b
Cumulative caloric intake for 9 days (kcal)		90.0±5.49^a	70.6±1.95^b	87.0±1.00^a	77.3±3.29^b	103.1±0.55^a,*	96.6±0.69^a	82.5±2.48^b	80.0±3.45^b
Visceral fat (g)		2.0±0.14^a	1.6±0.04^b	1.7±0.13^a,b	1.5±0.10^b	2.8±0.08^a,*	2.7±0.13^a	2.4±0.14^b	2.4±0.08^b
Plasma biochemical
Leptin (ng/mL)		10.4±3.22	5.9±1.71	7.7±1.96	4.2±1.58	20.5±2.24^a,*	20.2±2.21^a	13.0±1.69^b	12.6±0.91^b
Glucose (mg/dL)		282±21.8	251±21.3	266±16.7	252±12.7	318±22.9^a	320±18.2^a	279±13.3^a,b	264±14.4^b
T-cholesterol (mg/dL)		164±10.1	158±3.1	163±8.1	148±5.9	205±6.21^a,*	199±6.7^a	191±6.3^a	180±7.9^b

Values are expressed as mean±standard error of 7 mice per group.

^*p<0.05 vs. vehicle treated control mice. ^a,bThere were no significant differences between the same characteristics at p<0.05 within control or high-fat-fed mice.