Table 2.
Selected results showing the upregulation and downregulation of gene expression in functional pathway-related gene expression profiles
| Functional category | No. | Gene name | Symbol | Fold change |
||
|---|---|---|---|---|---|---|
| DDO | Non-DDO | BOO | ||||
| Apoptosis | 1 | Inhibin alpha | INHA | 0.825 | 8.932 | 2.177 |
| 2 | Interleukin 1 alpha | IL1A | 4.222 | 70.443 | 8.100 | |
| 3 | Cyclin-dependent kinase inhibitor 1A | CDKN1A | 1.994 | 0.298 | 0.500 | |
| Zinc finger protein | ZFP162 | 1.221 | 0.105 | 0.407 | ||
| V-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | ETS1 | 1.291 | 0.127 | 0.399 | ||
| Vascular endothelial growth factor A | VEGFA | 1.169 | 0.419 | 0.623 | ||
| Cell adhesion | 1 | Catenin (cadherin associated protein), beta 1 | CTNNB1 | 1.200 | 0.027 | 0.448 |
| Adhesion regulating molecule 1 | ADRM1 | 1.054 | 0.086 | 0.617 | ||
| Procollagen, type 1, alpha 1 | COL1A1 | 0.986 | 0.025 | 0.504 | ||
| 2 | Cadherin 3, type 1, P-cadherin (placental) | CDH3 | 1.390 | 0.289 | 0.480 | |
| Integrin, alpha 6 | ITGA6 | 1.371 | 0.137 | 0.258 | ||
| Integrin, alpha 6 | ITGA6 | 1.379 | 0.170 | 0.265 | ||
| A disintegrin and metalloprotease domain 10 | ADAM10 | 1.982 | 0.162 | 0.141 | ||
| Thrombospondin 4 | THBS4 | 0.938 | 1.723 | 3.422 | ||
| Chemokine and receptors | 1 | Chemokine (C-X-C motif) ligand 2 | CXCL2 | 1.676 | 26.387 | 5.688 |
| Chemokine (C-C motif) ligand 4 | CCL4 | 1.285 | 25.409 | 4.399 | ||
| Chemokine (C-C motif) ligand 3 | CCL3 | 1.454 | 25.222 | 2.741 | ||
| Paired-Ig-like receptor B | PIRB | 1.365 | 13.638 | 3.319 | ||
| Chemokine (C-C motif) ligand 5 | CCL5 | 1.605 | 7.253 | 2.049 | ||
| Chemokine (C-X-X motif) ligand 9 | CXCL9 | 1.391 | 5.630 | 2.220 | ||
| Chemokine (C-X-C motif) ligand 10 | CXCL10 | 1.163 | 4.343 | 23.849 | ||
| Chemokine (C-C motif) ligand 2 | CCL2 | 0.998 | 3.678 | 2.081 | ||
| Chemokine (C-C motif) receptor 5 | CCR5 | 0.890 | 0.799 | 0.438 | ||
| Chemokine (C-X-C motif) ligand 14 | CXCL14 | 0.959 | 0.490 | 0.495 | ||
| Colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage) | CSF2RB1 | 1.022 | 0.257 | 0.486 | ||
| Signal transducer and activator of transcription 5B | STAT5B | 1.027 | 0.208 | 0.456 | ||
| Extracellular matrix | 1 | Matrix extracellular phosphoglycoprotein with ASARM motif (bone) | MEPE | 1.327 | 0.048 | 0.551 |
| Procollagen, type 1, alpha 1 | COL1A1 | 0.986 | 0.025 | 0.504 | ||
| 2 | Biglycan | BGN | 0.939 | 0.020 | 0.282 | |
| Fibronectin 1 | FN1 | 1.587 | 0.023 | 0.353 | ||
| Procollagen, type XII, alpha 1 | COL12A1 | 1.147 | 0.042 | 0.332 | ||
| Transforming growth factor, beta 1 | TGFB1 | 1.128 | 0.075 | 0.735 | ||
| Integrin beta 4 | ITGB4 | 1.151 | 0.107 | 0.439 | ||
| 3 | Matrix metallopeptidase 12 | MMP12 | 2.895 | 31.046 | 6.216 | |
| Matrix metallopeptidase 7 | MMP7 | 8.358 | 163.101 | 12.037 | ||
| Matrix metallopeptidase 13 | MMP13 | 2.007 | 3.756 | 2.422 | ||
| Matrix metallopeptidase 8 | MMP8 | 2.710 | 7.228 | 3.778 | ||
| Inflammatory response | 1 | Chemokine (C-C motif) ligand 4 | CCL4 | 1.285 | 25.409 | 4.399 |
| Mast cell protease 6 | MCPT6 | 1.341 | 8.346 | 2.247 | ||
| Interleukin 1 alpha | IL1A | 4.222 | 70.443 | 8.100 | ||
| Ischemia-reperfusion | 1 | Lipocalin 2 | LCN2 | 1.987 | 5.604 | 5.292 |
| Midkine | MDK | 1.011 | 3.303 | 2.075 | ||
| PTK2 protein tyrosine kinase 2 | PTK2 | 1.101 | 0.181 | 0.245 | ||
| Neutrophil cytosolic factor 1 | NCF1 | 1.232 | 0.401 | 0.370 | ||
| Endothelin 1 | EDN1 | 0.966 | 12.292 | 2.462 | ||
| Angiopoietin 1 | ANGPT1 | 1.034 | 0.655 | 0.458 | ||
| Caspase 3, apoptosis related cysteine protease | CASP3 | 1.320 | 0.299 | 0.393 | ||
| Coagulation factor II (thrombin) receptor | F2R | 1.122 | 0.300 | 0.159 | ||
| Ectonucleoside triphosphate diphosphohydrolase 1 | ENTPD1 | 1.178 | 0.105 | 0.135 | ||
The numbers (No.) indicate the grouping of the differentially expressed patterns in each category.
DEO, total deobstructed group in rats with bladder outlet obstruction; DDO, DEO group showing DO during the storage phase; Non-DDO, DEO group showing no DO.