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. 2017 Dec;9(12):5322–5334. doi: 10.21037/jtd.2017.12.72

Table 3. Meta-analysis and subgroup analysis of short-term post-operation comparison of lung cancer patients with and without CPFE.

Variables N (study) N (case) N (control) Pooled data Heterogeneity
WMD/OR (95% CI) P I2 (%) Ph
Cause of death (LC vs. others) 4 143 1,257 2.99 (1.45, 6.20) 0.003 62 0.05
   CPFE vs. fibrosis 4 143 93 1.48 (−1.64, 1.02) 0.18 0 0.41
   CPFE vs. emphysema 3 88 408 2.38 (1.19, 3.42) 0.002 31 0.24
   CPFE vs. normal 3 88 756 5.17 (3.88, 6.02) <0.001 55 0.11
30-day mortality 5 417 4,343 4.72 (2.06, 10.85) <0.001 48 0.12
   CPFE vs. fibrosis 4 362 158 2.21 (2.83, 8.08) 0.3 0 0.75
   CPFE vs. emphysema 3 205 529 3.61 (1.3, 3.19) 0.22 55 0.14
   CPFE vs. normal 2 68 511 21.44 (9.63, 21.93) 0.008 NA NA
90-day mortality 4 360 3,715 5.33 (1.39, 20.42) 0.01 74 0.009
   CPFE vs. fibrosis 3 305 139 2.64 (2.11, 34.29) 0.07 31 0.24
   CPFE vs. emphysema 2 148 307 2.63 (1.14, 10.64) 0.05 0 0.8
   CPFE vs. normal 1 11 124 35.57 (20.44, 193.97) 0.03 NA NA
Complications 6 434 4,599 5.25 (2.38, 11.57) <0.001 87 <0.001
   CPFE vs. fibrosis 4 260 158 2.27 (0.91, 5.7) 0.08 66 0.03
   CPFE vs. emphysema 3 205 529 2.47 (1.72, 3.54) <0.001 10 0.33
   CPFE vs. normal 2 68 511 7.21 (1.26, 41.27) 0.03 69 0.07
AE 5 375 1,379 1.54 (0.34, 6.87) 0.57 78 0.001
   Pneumonia 4 260 2,163 4.49 (2.53, 7.95) <0.001 22 0.28
      CPFE vs. fibrosis 4 260 158 2.63 (0.95, 0.95) 0.06 0 0.52
      CPFE vs. emphysema 3 205 529 2.11 (1.14, 3.91) 0.02 0 0.54
      CPFE vs. normal 2 68 511 7.67 (3.38, 17.42) <0.001 0 0.34
   Pulmonary air leakage 3 249 1,925 4.55 (2.68, 7.73) <0.001 0 0.57
      CPFE vs. fibrosis 3 249 151 2.52 (1.07, 5.9) 0.03 0 0.47
      CPFE vs. emphysema 2 194 421 1.47 (0.5, 4.32) 0.48 66 0.09
      CPFE vs. normal 1 57 387 5.57 (1.86, 16.71) 0.002 NA NA

a, numbers of studies included in the meta-analysis; b, number of patients of CPFE group; c, number of patients of non-CPFE group. LC, lung cancer; OR, odds ratio; 95% CI, confidence interval; P, P value of pooled HR; I2, value of χ2 based I-squared statistics; Ph, P value of Heterogeneity test; CPFE, combined pulmonary fibrosis and emphysema; NA, not available.