Table 5. Univariate and multivariate analyses of prognostic factors using the Cox proportional hazards model for all stage IV NSCLC patients.
| Variables | Characteristics | Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Unfavorable | Favorable | 95% CI | HR | P | 95% CI | HR | P | |||
| Gender | Male | Female | 0.044–0.800 | 0.187 | 0.0113 | 0.056–1.397 | 0.28 | 0.1206 | ||
| Age (years) | ≥68 | <68 | 0.427–2.122 | 0.952 | 0.9035 | – | – | – | ||
| Surgical procedure | Over lob. | Sublob. | 0.231–2.071 | 0.692 | 0.5084 | – | – | – | ||
| Histology | SCC | Non-SCC | 0.072–0.612 | 0.209 | 0.0017 | 0.071–0.697 | 0.223 | 0.0098 | ||
| EGFR | Negative or unknown | Positive | 0.029–1.578 | 0.212 | 0.0949 | 0.033–2.205 | 0.268 | 0.2208 | ||
| T status | 3–4 | 1–2 | 0.413–2.156 | 0.944 | 0.8905 | – | – | – | ||
| N status | Positive | Negative | 0.214–1.181 | 0.502 | 0.1077 | 0.193–1.457 | 0.53 | 0.2183 | ||
| M status | M1b + M1c | M1a | 0.408–2.046 | 0.913 | 0.3511 | 0.200–1.242 | 0.499 | 0.1351 | ||
| M category | M worse | M better | 0.087–0.573 | 0.223 | 0.0007 | 0.068–0.721 | 0.222 | 0.0123 | ||
95% CI, 95% confidence interval; HR, hazard ratio; Sublob, sublobar resection; lob., lobectomy; SCC, squamous cell carcinoma; EGFR, epidermal growth factor receptor.