Table 2. Definition and diagnostic certainty of clinical pulmonary AMR depending on criteria present*.
| AMR Grade | Allograft dysfunction | Other causes excluded | Lung histology | Lung biopsy C4d | DSA |
|---|---|---|---|---|---|
| Definite | X | X | X | X | X |
| Probable | X | X | X | O | X |
| Probable | X | X | X | X | O |
| Probable | X | X | O | X | X |
| Probable | X | O | X | X | X |
| Possible | X | X | X | O | O |
| Possible | X | X | O | O | X |
| Possible | X | X | O | X | O |
| Possible | X | O | X | X | O |
| Possible | X | O | X | O | X |
| Possible | X | O | O | X | X |
*, adapted from the 2016 pulmonary AMR consensus document of the ISHLT. X, absent; O, present. AMR, antibody-mediated rejection; DSA, donor-specific antibodies.