FIG. 5.

(A) Measurements of Thy1-CFP fluorescence in retinal flat mounts at 1 and 6 weeks after blast. The micrographs on the right are representative of the hyper-fluorescence seen 1 week after blast. Arrows indicate Thy1-CFP positive cells with very large somata. Scale bar = 100 μm. Control versus Blast at 1 week, p < 0.001, n = 3 per condition. (B) Automated retinal ganglion cell (RGC) soma size measurements at 1 and 6 weeks after blast. Soma size is significantly larger at 1 week after blast but significantly smaller at 6 weeks after blast. (C) Visual acuity and contrast sensitivity 6 weeks after blast. Both measures drop significantly after compared with a control situation. (D) RGC counts in retinal Thy1-CFP flat mounts. There is a significant drop 6 weeks after mice have been subjected to blast injury. Color image is available online at www.liebertpub.com/neu