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. 2018 Jan 1;35(1):32–40. doi: 10.1089/neu.2017.4994

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Copyright 2018, Mary Ann Liebert, Inc.

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FIG. 4. — (A) Boxplot of levels microtubule-associated protein 2 (MAP-2) levels versus Marshall Classification. Overall, there were significant differences between the groups for both initial MAP-2 levels (p = 0.05) and maximal 24-h levels in cerebrospinal fluid (p = 0.008). Levels were highest among patients with diffuse injury, compared with those with mass lesions. Among the diffuse injury group, those with Diffuse Injury III-IV had higher initial (p = 0.115) and maximal (p = 0.007) MAP-2 levels than those with Diffuse Injury I-II. Boxplots represent medians with interquartile ranges. (B) Pattern of biomarker release over 10 days versus Marshall Classification. There is a graded increase in the overall levels and the peaks of MAP-2 as the degree of diffuse injury increases. This is mostly seen within the first 120 h post-injury. Also, MAP-2 levels were slightly higher in non-evacuated mass lesions than evacuated mass lesions. Lines represent mean values of MAP-2 over time.