Table 6.
Univariate and multivariate analyses of 211 pathological T4 colorectal cancer patients for disease-free survival
|
Univariate analysis |
Multivariate analysis |
|||
| Variable | HR (95%CI) | P value | HR (95%CI) | P value |
| Age | 1.621 (1.010-2.601) | 0.045 | 1.892 (1.111-3.223) | 0.419 |
| Gender | 1.328 (0.824-2.141) | 0.243 | ||
| Surgical method (LAP and OPEN) | 1.503 (0.933-2.422) | 0.094 | ||
| Tumor location | ||||
| Mid/upper rectum | Reference group | - | ||
| Left colon | 1.010 (0.601-10697) | 0.969 | ||
| Right colon | 0.818 (0.411-1.629) | 0.568 | ||
| Comorbidities | 1.787 (1.058-3.019) | 0.030 | 2.261 (1.235-4.139) | 0.080 |
| pT4a/b | 0.818 (0.618-1.725) | 0.013 | 1.214 (0.784-1.974) | 0.001 |
| N stage | ||||
| N0 | Reference group | - | ||
| N1 | 1.134 (0.594-2.167) | 0.703 | ||
| N2 | 1.553 (0.861-2.801) | 0.144 | ||
| TNM stage | ||||
| IIB + IIC | Reference group | - | Reference group | - |
| IIIB | 1.034 (0.471-2.269) | 0.933 | 0.884 (0.393-1.989) | 0.765 |
| IIIC | 2.284 (1.202-4.337) | 0.012 | 1.831 (0.935-3.584) | 0.018 |
| Lymph node status | 0.710 (0.411-1.229) | 0.221 | ||
| No. of lymph nodes resected | 0.661 (0.411-1.061) | 0.087 | ||
| Histological subtype | 0.456 (0.243-0.854) | 0.014 | 0.469 (0.225-0.974) | 0.042 |
| Differentiation | 0.439 (0.266-0.725) | 0.001 | 0.662 (0.374-1.170) | 0.156 |
| CA19-9 | 2.458 (1.526-3.960) | 0.000 | 3.372 (1.968-5.778) | 0.000 |
| CEA | 1.268 (0.790-2.036) | 0.326 | 0.608 (0.356-1.038) | 0.072 |
| Chemotherapy | 2.157 (1.323-3.514) | 0.002 | 3.817 (2.194-6.639) | 0.000 |
CRC: Colorectal cancer; LAP: Laparoscopic surgery; OPEN: Open surgery; p-Pathological; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; HR: Hazard ratio.