Figure 1.

Therapeutic approaches by genome editing. There are two possible approaches of genome editing in cardiovascular diseases. (a) Somatic cells can be isolated from patients and reprogrammed in iPS cells. The patient-specific iPSCs can be modified ex vivo, and after the editing they can be differentiated and transplanted back into the patient. (b) The mutations can be directly edited in vivo, delivering the complex CRISPR/Cas9 system-delivery tool at the desired genomic site in the specific tissue.