Figure 3.

Amino acid metabolism and TCA cycle. (a) Box plots representing relative amounts of metabolites participating in the tryptophan-kynurenin pathway across molecular subtypes. p values refer to one-way ANOVA on raw data. (b) Relative differences in TCA metabolic intermediates across molecular subtypes. Data for basal-like, HER2-enriched, and luminal B tumors expressed as fold changes of raw data peak intensities with respect to the luminal A subtype are reported for each metabolic intermediate. Statistical significance of differences between mean values for each reported comparison was tested by the Welch t-test. Color codes refer to the range of calculated p values and to the direction of the differences between means, as detailed in the figure inset. AU = arbitrary units.