Figure 7.

Illustration and bioapplications of ¹⁸F-nGO-PEG.

Notes: (A) Representation of different mechanisms by which imaging agents can be delivered to tumors. ¹⁸F-nGO-PEG is shown as a representative radiotracer. Passive tissue targeting is achieved by the extravasation of nanoparticles through the increased permeability of the tumor vasculature (EPR effect). (B) Representative whole-body PET image of a CT26 tumor-bearing mice at 15 minutes after an intravenous injection. The letter “T” indicates the location of the tumor.

Abbreviations: EPR, enhanced permeability and retention; nGO, nano-graphene oxide; PEG, polyethylene glycol; PET, positron-emission tomography.