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. 2018 Jan 3;11:185–191. doi: 10.2147/OTT.S145780

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© 2018 Bimonte et al. This work is published and licensed by Dove Medical Press Limited

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Naloxone inhibits proliferation and increases apoptosis in MDA.MB231 cells in a dose-dependent manner.

Notes: (A) 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay results show an enhancement of proliferation in breast cancer cells treated with naloxone with respect to Ctr cells. Data are representative of three independent experiments. (B) In vitro apoptosis assay by flow cytometry showed the effect of the naloxone on MDA-MB.231 cell’s apoptosis. The treatments with naloxone at 100 μM enhanced the apoptosis level on the breast cancer cell line. Data presented as mean ± SD. Significance: ^**P<0.01 and ^***P<0.001 by analysis of variance, compared with Ctr.

Abbreviation: Ctr, control.