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. 2017 Dec 18;19(1):3–4. doi: 10.15252/embr.201745497

Figure 1. Nup62 prevents SCC differentiation by modulating ∆Np63α nuclear transport.

Figure 1

In undifferentiated SCC cells, the NPC component Nup62 interacts with the transcription factor ∆Np63α to mediate its nuclear import. Once inside the nucleus, ∆Np63α drives the expression of genes that maintain the proliferative capacity and stemness of SCCs. Upon differentiation, ROCK phosphorylates Nup62 in two FG domain residues, reducing the association of Nup62 with ∆Np63α. This impairs ∆Np63α nuclear import, which subsequently causes expression of differentiation genes 1.