Figure 6. Model of T function in early mesodermal development.

1. Schematic illustrating T‐mediated recruitment of p300 and H3K27ac in nascent mesoderm to target loci involved in development of cell types derived from the mesoderm, including hematopoietic, endothelial, and cardiovascular cells.
2. Schematic illustrating our proposed model showing that in wild‐type T mesodermal cells, recruitment of H3K27ac occurs at target loci. In the T ^Y88A mutant mesodermal cells, less H3K27ac is recruited to T target loci and there is less T^Y88A protein present. The X represents speculation that the Y88A mutation disrupts the interaction between T and p300.