Figure 1.

Treatment with exendin-4 in NMRI mice decreased serum glucose (a), insulin and HOMA-IR (b), and increased insulin secretion by pancreatic islets cultured in medium containing different concentrations of glucose (c). Data are expressed as the mean ± SEM of 12 mice in each group for glucose, insulin and, HOMA-IR, and 8 samples for islet insulin secretion. Data were analyzed using one-way analysis of variance and least significant difference tests. * p < 0.05 and ** p < 0.01 designate significant differences with D-galactose treatment group, ^# p < 0.05 designates significant differences with the control group.