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. 2018 Jan 8;11:1. doi: 10.1186/s13072-017-0171-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Hypothetical pathway related with cell stress and death identified with altered DNA methylation and/or genes transcripts in the FBL in comparison with SBL. Black circle represents hypermethylated genes; gray circle represents hypomethylated genes; white circle represents genes without difference in DNA methylation; blue triangle represents genes up-regulated; red triangle represents genes down-regulated; gray square represents genes without difference in RNA levels. Graphs show the difference in expression of DDIT3, NFE2L2, GPX1, TXNRD1, NOS2, BAX, BID, FOXO3, CASP9, and HSPA1A for FBL and SBL (*P ≤ 0.1; **P ≤ 0.05; ***P ≤ 0.01)