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. 2017 May 17;38(1):58–74. doi: 10.1177/0271678X17705973

Figure 4.

Figure 4.

Restored cerebral blood flow and preserved brain vascular density by mTOR attenuation in LDLR−/− mice. (a) Profound CBF deficits in 12 month old LDLR−/− mice were restored to levels indistinguishable from those of WT mice as a result of chronic rapamycin treatment (F(2,7) = 21.22, p = 0.001, Tukey’s test, one-way ANOVA); (b–c) Reduced BVD (calculated as S = ΔR2/(ΔR2*)2/3) in control-treated but not in rapamycin-treated LDLR−/− mice (F(2,7) = 41.48, p = 0.0001, Tukey’s test, one-way ANOVA; (b) Representative MRI angiograms; (c) Quantitative analyses of angiogram data. n = 3–4. Data are means ± SEM. N.B. Data for the single surviving HFD-fed rapamycin-treated LDLR−/− animal are provided (a,c) but were not included in the ANOVA. Values for WT CBF (a) and BVD (c) are included as a reference and correspond to measures performed on separate groups of WT C57Bl/6 J mice of comparable age; these values were not included in the ANOVA.