Table 3.

Correlation between continuous clinical characteristics and mean K2 coefficients and mean ADC values in normal appearing white matter.

	Mean K2 coefficients (×10−6) in NAWM		Mean ADC (×10−6) in NAWM
	Spearman’s coefficient	P	Spearman’s coefficient	P
DWI lesion volume	0.15	0.04	0.03	0.72
MTT lesion volume	0.21	0.0035	0.049	0.51
Contralateral WMH volume	0.19	0.010	0.51	<0.0001
Mean ADC in NAWM	0.23	0.0014	–	–
Age	0.26	0.0004	0.61	<0.0001
Systolic blood pressure	−0.004	0.96	0.17	0.024
Diastolic blood pressure	−0.10	0.17	0.05	0.47
Creatinine	−0.067	0.37	0.089	0.23
Body mass index	−0.21	0.0064	−0.054	0.52
NIHSS score	0.19	0.0099	0.21	0.0043
MMP-2 (Baseline), ng/mL	0.17	0.022	0.37	<0.0001
MMP-2 (48 h), ng/mL	0.084	0.32	0.32	0.0001

ADC: apparent diffusion coefficient; DWI: diffusion-weighted imaging; IQR: interquartile range; MMP-2: matrix metalloproteinase 2; mRS: modified Rankin Scale score; MTT: mean transit time; NAWM: normal-appearing white matter; NIHSS: National Institutes of Health Stroke Scale; SD: standard deviation; WMH: white matter hyperintensity.