Table 1.
Experiment | Included | Total | Died | Excluded | Mean lesion size % of contralateral hemisphere |
---|---|---|---|---|---|
Dose | after 72 h | ||||
Vehicle | 45 | 51 | 3 | 3 | 44 |
1 mg/kg | 13 | 16 | 2 | 1 | 41 |
10 mg/kg | 13 | 15 | 0 | 2 | 35 |
30 mg/kg | 13 | 13 | 0 | 0 | 35 |
100 mg/kg | 14 | 15 | 1 | 0 | 41 |
Time point | after 72 h | ||||
Vehicle | 21 | 24 | 2 | 1 | 46 |
0 h | 8 | 8 | 0 | 0 | 43 |
3 h | 12 | 12 | 0 | 0 | 37 |
6 h | 12 | 12 | 0 | 0 | 48 |
12 h | 11 | 11 | 0 | 0 | 55 |
24 h | 10 | 10 | 0 | 0 | 54 |
Knock-out | after 72 h | ||||
KO Vehicle | 15 | 20 | 5 | 0 | 50 |
KO 10 mg/kg | 13 | 20 | 4 | 3 | 56 |
WT Vehicle | 8 | 10 | 1 | 1 | 49 |
WT 10 mg/kg | 8 | 10 | 1 | 1 | 35 |
Long-term outcome | after 28 days | ||||
Vehicle | 6 | 10 | 4 | 0 | 28 |
10 mg/kg | 9 | 10 | 1 | 0 | 37 |
Total | 231 | 267 | 24 | 12 |