Table 2.
Summary of FLIP methods and results of studies evaluating EGJ-distensibility in asymptomatic controls.
| Author, year |
N |
1FLIP length, cm |
IP channel spacing, mm |
2Test setting, sedation |
Placement | Pressure zero |
Fill volume, ml |
3EGJ-DI, mm2/mmHg |
Comparator group |
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Beaumont, 200935 | 10 | 6.4 | 4 | awake | oral | gastric | 10–60 | 3.7 +/− 0.9 | Barrett’s, post-ablation |
|
| |||||||||
| Kwiatek, 20104 | 20 | 6.4 | 4 | Endoscopy, Conscious | Oral | Gastric | 10 | 3.2 (2.3 – 6.7) | GERD |
| 20 | 2.2 (1.2 – 6.5) | ||||||||
| 30 | 4.2 (1.7 – 10.4) | ||||||||
| 40 | 7.3 (3.8 – 11.4) | ||||||||
|
| |||||||||
| Kwiatek, 201113 | 15 | 8 | 5 | Endoscopy, Conscious | Oral | NR | 20 | 0.9 (0.3 – 1.4) | EoE |
| 30 | 0.8 (0.4 – 2.8) | ||||||||
|
| |||||||||
| Rohof, 20125 | 15 | 6.4 | 4 | Awake | Nasal | Atm | 50 | 6.3 +/− 0.7 | Achalasia |
|
| |||||||||
| Nathanson, 201236 | 50 | 8 | 5 | Intra-operative, General anesthesia | Oral | Gastric | 30 | 1.1 (0.7 – 1.6) | -- |
| 40 | 1.2 (0.83 – 2.2) | ||||||||
|
| |||||||||
| Tucker, 20137 | 22 | 6.4 | 4 | Endoscopy, Conscious | Oral | NR | 20 | 4.0 (2.4 – 7.5) | GERD |
| 30 | 6.1 (4.3 – 8.0) | ||||||||
|
| |||||||||
| Rieder, 201315 | 4 | 8 | 5 | Awake | Oral | NR | 30 | 2.5 (2.0 – 6.3) | Achalasia |
| 40 | 2.7 (2.4 – 8.3) | ||||||||
|
| |||||||||
| Fukazawa, 201437 | 9 | 8 | 5 | Awake | Nasal | Atm | 20 | 2.9 +/− (0.6) | Intra-subject following mosapride |
| 40 | 7.1 +/− (0.9) | ||||||||
| 50 | 8.2 +/− (0.8) | ||||||||
|
| |||||||||
| Lottrup, 201538 | 10 | 8 | 5 | Awake | Oral | Atm | 20 | 1.9 +/− 0.5 | GERD, hiatal hernia |
| 30 | 2.8 +/− 0.6 | ||||||||
| 40 | 3.8 +/− 0.9 | ||||||||
| 50 | 3.9 +/− 0.7 | ||||||||
|
| |||||||||
| Carlson, 201511 | 10 | 16 | 10 | Endoscopy, Conscious | Oral | Atm | 50 | 7.1 (3.8 – 8.9) | Achalasia |
| 60 | 6.2 (4.6 – 8.1) | ||||||||
|
| |||||||||
| Mikami, 201639 | 9 | 6.4 | 4 | Awake | Nasal | Atm | 20 | 1.8 +/− (0.2) | Intra-subject following metoclopramide |
| 30 | 3.5 +/− (0.6) | ||||||||
| 40 | 4.5 +/− (0.5) | ||||||||
1
Length of the cylindrical, measurement segment.
2
Conscious sedation with midazolam and fentanyl or pethidine.
3
Results extrapolated from figures if not directly reported and represented as median (inter-quartile range) or mean +/− SD (SE).
IP – impedance planimetry. NR – not reported. Atm – atmospheric.
*
Courtesy of Dustin Carlson