Fig. 4.

Interstitial cell proliferation was diminished in the IRI kidneys from S100A4-FGFR2−/− mice. a Representative immunohistochemical staining images showing Ki-67-positive cells in the kidneys from S100A4- FGFR2−/− mice and control littermates. b Graph showing quantitative results for Ki-67-positive cells in the kidneys. C, cortical area; M, medullary area; T, tubule; I, interstitium. Data are presented as number of Ki-67-positive cells per HPF (×400). * p < 0.05 versus control littermates, n = 4. FGFR, fibroblast growth factor receptor; HPF, high-power field; IRI, ischemia/reperfusion injury.