Fig. 5.

Interstitial cell apoptosis was less in mice with fibroblast-specific ablation of FGFR2 after IRI. a Representative micrographs showing TUNEL staining for apoptotic cells in the kidneys from S100A4-FGFR2−/− mice and control littermates. Arrows indicate apoptotic cells in the kidneys. b Graph showing the quantitative results for TUNEL-positive cells in the kidneys. C, cortical area; M, medullary area; T, tubule; I, interstitium. Data are presented as TUNEL-positive cell number per HPF (×400). * p < 0.05 versus control littermates, n = 4. FGFR, fibroblast growth factor receptor; HPF, high-power field; IRI, ischemia/reperfusion injury.