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. 2017 Dec 26;137(1):57–70. doi: 10.1161/CIRCULATIONAHA.117.028911

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© 2017 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 3. — Runx1^Δ/Δ mice cardiac structure 8 weeks after myocardial infarction (MI). A, Picrosirius Red–stained hearts. Scale, 1 mm. BZ indicates border zone; INF, infarct; LV, left ventricle; RV, right ventricle; and SEP, septum. Mean (B) area of whole heart (all regions), (C) LV, (D) RV, and (E) LV wall thickness at BZ region; (F) septum wall thickness at BZ region level; (G) ratio of heart weight to body weight; (H) infarct thickness; (I) LV fibrosis; and (J) infarct size (Runx1^fl/fl MI and Runx1^wt/wt MI combined [n=12], Runx1^Δ/Δ MI [n=5]). *P<0.05, Student t test. K, Wheat germ agglutinin (WGA) staining of LV cardiomyocytes (longitudinal) of Runx1^fl/fl MI (top) and Runx1^Δ/Δ (bottom) after MI (scale bar, 25 mm). L, Mean LV cardiomyocyte length (Runx1^Δ/Δ sham [n=55 cardiomyocytes, n=3 hearts], Runx1^fl/fl MI [n=122 cardiomyocytes, n=6 hearts], Runx1^wt/wt MI [n=109 cardiomyocytes, n=6 hearts], Runx1^Δ/Δ MI [n=102 cardiomyocytes, n=6 hearts]). *P<0.05, linear mixed modeling. M, Mean SEP cardiomyocyte length (Runx1^Δ/Δ sham [n=29 cardiomyocytes, n=3 hearts], Runx1^fl/fl MI [n=82 cardiomyocytes, n=6 hearts], Runx1^wt/wt MI [n=84 cardiomyocytes, n=6 hearts], Runx1^Δ/Δ MI [n=64 cardiomyocytes, n=6 hearts]). N, WGA staining of LV cardiomyocytes (transverse) of Runx1^wt/wt MI (left) and Runx1^Δ/Δ MI (right; scale bar, 25 mm). O, Mean LV cardiomyocyte diameter (Runx1^Δ/Δ sham [n=449 cardiomyocytes, n=3 hearts], Runx1^fl/fl MI [n=811 cardiomyocytes, n=6 hearts], Runx1^wt/wt MI [n=897 cardiomyocytes, n=6 hearts], Runx1^Δ/Δ MI [n=878 cardiomyocytes, n=6 hearts]). P, Mean LV cardiomyocyte cross-sectional area (Runx1^Δ/Δ sham [n=403 cardiomyocytes, n=3 hearts], Runx1^fl/fl MI [n=714 cardiomyocytes, n=6 hearts], Runx1^wt/wt MI [n=785 cardiomyocytes, n=6 hearts], Runx1^Δ/Δ MI [n=699 cardiomyocytes, n=6 hearts]). Q, Mean SEP cardiomyocyte diameter (Runx1^Δ/Δ sham [n=238 cardiomyocytes, n=3 hearts], Runx1^fl/fl MI [n=465 cardiomyocytes, n=6 hearts], Runx1^wt/wt MI [n=454 cardiomyocytes, n=6 hearts], Runx1^Δ/Δ MI [n=452 cardiomyocytes, n=6 hearts]). *P<0.05, linear mixed modeling.