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. 2018 Jan 8;137(2):166–183. doi: 10.1161/CIRCULATIONAHA.116.023381

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© 2017 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — ECM composition in DES and BMS in the media. A, Volcano plot of differentially expressed proteins between DES and BMS at day 28. n=3 per group (t test with unequal variance). B, Changes in aggrecan, versican, and HPLN1 protein abundance at day 1, 3, 7, and 28 post–stent implantation. n=3 per group. *P<0.05 (t test with unequal variance). C, Corresponding gene expression in stented (n=3 per time point) and control unstented coronary arteries (n=6). Gene expression values were normalized to unstented control arteries. Linear regression analysis for P value for trend. BMS indicates bare-metal stent; DES, drug-eluting stent; ECM, extracellular matrix; HAPLN1, gene name for hyaluronan and proteoglycan link protein 1; HPLN1, hyaluronan and proteoglycan link protein 1; and PGCA, aggrecan; and TIC, total ion current.