Figure 7.

Aggrecan and aggrecanases in the murine aorta. A, Volcano plot of differentially expressed proteins between the aorta of wild-type littermate controls (WT) and mice lacking the catalytic domain of ADAMTS-5 (Adamts5 Δcat). n=6 (WT), n=5 (Adamts5 Δcat), t test with unequal variance. PGCA indicates aggrecan; MIME, mimecan; and VTNC, vitronectin. B, Aortic diameters of aortic ring (AoR), ascending aorta (AsAo), and abdominal aorta (AbAo) as measured by ultrasonography. Representative ultrasound images are shown, values are represented as box-and-whisker plots. n=5 per group *P<0.05 (t test with unequal variance).