Table 2.
Diagnostic performance of Triacetylfusarinine C (TAFC), Aspergillus specific Lateral Flow Device Test (LFD), galacto-mannan enzyme immunoassay (GM) and conventional microbiological culture (culture) in bronchoalveolar lavage fluid (BALF) samples as single tests or in distinct combinations.
| Biomarkers/tests and combinations | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| TAFC | 40% (6/15) | 79% (23/29) | 50% (6/12) | 72% (23/32) |
| LFD | 47% (7/15) | 79% (23/29) | 54% (7/13) | 74% (23/31) |
| GM (0.5 ODI)a | 73% (11/15) | 97% (28/29) | 92% (11/12) | 88% (28/32) |
| GM (1.0 ODI)a | 53% (8/15) | 97% (28/29) | 89% (8/9) | 80% (28/35) |
| Fungal culturea | 13% (2/15) | 100% (29/29) | 100% (2/2) | 69% (29/42) |
| TAFC and/or GM (0.5 ODI) | 87% (13/15) | 76% (22/29) | 65% (13/20) | 92% (22/24) |
| TAFC and/or GM (1.0 ODI) | 73% (11/15) | 76% (22/29) | 61% (11/18) | 85% (22/26) |
| LFD and/or GM (0.5 ODI) | 93% (14/15) | 76% (22/29) | 67% (14/21) | 96% (22/23) |
| LFD and/or GM (1.0 ODI) | 73% (11/15) | 76% (22/29) | 61% (11/18) | 85% (22/26) |
| TAFC and/or LFD | 67% (10/15) | 62% (18/29) | 48% (10/21) | 78% (18/23) |
| TAFC and/or LFD and/or GM (1.0 ODI) | 80% (12/15) | 59% (17/29) | 50% (12/24) | 75% (17/20) |
a
In contrast to TAFC and LFD, GM and culture are part of the mycological criteria of the EORTC/MSG criteria and were therefore used for classification of IPA leading to potential overestimation of diagnostic performance.