Extended Data Figure 6. CCM formation can be stimulated by IL-1β or poly(I:C) treatment.

a, Schematic of the experimental design in which littermates receive a retro-orbital injection of the indicated cytokine or TLR ligand at P5 and P10 prior to tissue harvest and analysis at P17. b–m, Visual images and volumetric quantitation of CCM lesions in the hindbrains of P17 iECre;Ccm2^fl/fl littermates injected with the indicated cytokines, TLR ligands, or vehicle control are shown. Error bars shown as s.e.m. and significance determined by unpaired, two-tailed Student’s t-test. *indicates p<0.05; n.s. indicates p>0.05. Scale bars, 1 mm.