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. Author manuscript; available in PMC: 2018 Jan 8.
Published in final edited form as: Nature. 2017 May 10;545(7654):305–310. doi: 10.1038/nature22075

Figure 2. CCM lesion formation requires endothelial TLR4/CD14 signaling.

Figure 2

a, Injection of LPS at P5 drives CCM formation by P6 in susceptible iECre;Krit1fl/fl littermates. Scale bars, 1mm (white) and 50 μm (yellow). Arrows and arrowheads; CCM lesions. Dotted lines; cerebellar white matter. b, Gene expression in cerebellar endothelial cells isolated from the indicated littermates at P6. N≥3 per group. c–f, Genetic rescue of CCM formation with endothelial loss of TLR4 or global loss of CD14. Visual appearance of CCM lesions (above), corresponding microCT images (below), and lesion volume quantitation. Scale bars, 1mm. Error bars shown as s.e.m and significance determined by one-way ANOVA with Holm-Sidak correction for multiple comparisons. ****indicates p<0.0001; ***indicates p<0.001; **indicates p<0.01; n.s. indicates p>0.05.

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