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. Author manuscript; available in PMC: 2018 Jan 8.
Published in final edited form as: Nature. 2017 May 10;545(7654):305–310. doi: 10.1038/nature22075

Figure 3. Increased TLR4 or CD14 expression is associated with higher lesion number in familial CCM patients.

Figure 3

a, SNPs in the 5′ genomic regions of TLR4 and CD14 associated with increased lesion numbers in familial CCM patients are shown relative to the transcriptional start site (TSS). b–c, Normalized microarray measurement of TLR4 and CD14 expression in whole blood cells from individuals in the general population with the indicated TLR4 rs10759930 and CD14 rs778587 genotypes. d, Representative MRI images of KRIT1 Q455X patients with raw lesion count and TLR4/CD14 SNP genotypes (RA; risk allele). e–f, Sex and age adjusted log(lesion burden) in KRIT1 Q455X patients with indicated genotypes. Error bars shown as 95% confidence intervals and significance determined by one-way ANOVA with Holm-Sidak correction for multiple comparisons. ****indicates p<0.0001; ***indicates p<0.001; **indicates p<0.01; *indicates p<0.05.