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. Author manuscript; available in PMC: 2018 Jan 8.
Published in final edited form as: Nature. 2017 May 10;545(7654):305–310. doi: 10.1038/nature22075

Figure 5. CCM susceptibility is associated with increased levels of gram negative Bacteroidetes s24-7.

Figure 5

a–c, Visual and microCT images of hindbrains from susceptible (top) and resistant (bottom) iECre;Krit1fl/fl and iECre;Ccm2fl/fl animals and susceptible iECre;Krit1fl/fl animals fostered to conventional Swiss-Webster (SW) mothers. Scale bars, 1 mm. d–e, Quantitation of lesion and brain volumes. Error bars shown as s.e.m. and significance determined by one-way ANOVA with Holm-Sidak correction for multiple comparisons. f–g, Principle Coordinates Analysis (PCoA) of unweighted and weighted UniFrac bacterial composition distances from the feces of susceptible and resistant Krit1fl/fl and Ccm2fl/fl mothers. P-values compare bacterial compositions in all resistant to all susceptible animals using PERMANOVA. h, Relative abundance boxplot of Bacteroidetes s24-7 in susceptible or resistant Krit1fl/fl or Ccm2fl/fl mothers and conventional SW foster mothers. Significance determined by linear mixed effects model with Benjamini-Hochberg correction for multiple comparisons. ****indicates p<0.0001; ***indicates p<0.001; n.s. indicates p>0.05. Note: Conventional SW data from Figs. 4 and 5 are the same experiment.