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MIP image of a 65-year-old male with DLBCL on chemotherapy. Interim PET/CT was performed at an outside institution. The outside report indicated “no evidence of disease.” A second-opinion review at our institution reported heterogenous uptake in the bone marrow (arrowheads) suspicious for residual lymphomatous infiltration, concordant with the multidisciplinary staging as “stage IV” and with bone marrow biopsy results.
