Table 3.
Effects of single herb and compound Chinese medicinal preparations on NSC proliferation and differentiation.
| Classification | TCM | Affected cell type | Effect on NSCs | Main mechanisms | In vivo or in vitro | Refs. |
|---|---|---|---|---|---|---|
| Compound Chinese medicinal preparations | BuyangHuanwu Decoction | NSCs and NSPCs | Promote the proliferation and differentiation of NSCs and NSPCs | Decrease the content of Ca2+ in the cells, and increase the expression of NF and GFAP. | In vivo and in vitro | [177-179] |
| Jiawei Sini San | NPCs | Promote the proliferation of NPCs and inhibit apoptosis | The expression of nestin, beta-tubulin-III, and fibrillary acidic protein glial were significantly increased | In vitro | [180] | |
| Shengyu decoction | NSCs and NSPCs | Promote the proliferation of NSCs/NSPCs and their differentiation into neurons | Increase the expression of TN-C, GDNF, NCAM, and NGF, and inhibits the expression of Nogo-A | In vivo | [181] | |
| FuzhiSan | NSPCs | Promote the proliferation of NSPCs; Improve the survival rate of newborn cells | Promote the neurogenesis in hippocampus | In vivo | [182] | |
| XiehuoBushenDecocfion | NSCs | Promote the survival and differentiation of NSCs | Enhance the expression of IL-4 mRNA, and down-regulate the expression of IFN-gama mRNA | In vivo and in vitro | [27] | |
| PMC-12 | NSPCs | Promote the proliferation of NSPCs in the hippocampus; Improve the survival rate of newborn nerve cells |
Increased levels of BDNF, p-CREB and synaptophysin | In vivo | [183] | |
| Single herb | Salvia miltiorrhiza Bge | NSCs | Promote the differentiation of induced multifunctional NSCs into neurons in vitro; Promote the survival, collection and differentiation of NSCs derived from multifunctional stem cell | Increase the expression of nestin and MAP2 |
In vivo and in vitro | [22] |
| Sambucus williamsii Hance | NSCs | Promotethe differentiationof NSCs into neurons | Up-regulate the expression of Tuj1 and nestin genes, and down-regulate the expression of Oct4 and Sox2 genes | In vitro | [184] | |
| Scutellariacalensis Georgi, Phellodendronchinense Schneid, Ligusticumwallichii Franch | NSCs and NPCs | Promote the proliferation of NSCs and NPCs | Modulate HPA axis and increase the content of corticosterone | In vivo and in vitro | [23] |
The table lists effects of single herb and compound Chinese medicinal preparations on the NSC proliferation and differentiation, and underlying mechanism, and the cell type they affected; PMC-12, polygonummultiflorum Thunberg complex composition-12; Tuj1, tubulin-1; MAP2, microtubule-associated protein 2; HPA, hypothalamus-pituitary-adrenal; NF, neurofilament; GFAP, glial fibrillary acidic protein; TN-C, Tenascin-C; GDNF, glial cell line-derived neurotrophic factor; NVAM, neural cell adhesion molecule; NGF, Nerve growth factor; BDNF, brain derived neurotrophic factor; p-CREB, phosphorylated cAMP-response element binding protein.