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. 2017 Oct 20;191(2):180–188. doi: 10.1111/cei.13058

Figure 1.

Figure 1

Total innate lymphoid cell (ILC) frequencies and absolute numbers are similar in anti‐neutrophil cytoplasm autoantibody (ANCA)‐associated vasculitis (AAV) patients and control subjects. (a) Flow cytometry gating strategy used for ILC detection. After gating on lymphocytes and live cells, the distinct ILC populations were defined as: total ILCs (Lin1–CD127+); ILC1 (Lin1–/CD127+/CRTH2–/c‐Kit–); ILC2 (Lin1–/CD127+/CRTH2+/CD161+); ILC3 (Lin1–/CD127+/CRTH2–/c‐Kit+/NKp44+) and LTi (Lin1–/CD127+/CRTH2–/c‐Kit+/NKp44–). (b) Frequencies of ILC subsets in healthy controls (HC), disease controls (DC) and AAV patients in active (AP) and remission phase (RP). AAV subtypes are denoted by circle colour as GPA (Inline graphic) MPA (○) and EGPA (Inline graphic). (c) Absolute cell counts of ILC subsets in DC and AAV patients in active (AP) and remission phase (RP). Data represent median and interquartile range. One‐way analysis of variance (anova) was carried out using the non‐parametric Kruskal–Wallis test and Dunn's multiple comparison post‐test, **P < 0·01; *P < 0·05. [Colour figure can be viewed at wileyonlinelibrary.com]