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. 2017 Oct 20;191(2):180–188. doi: 10.1111/cei.13058

Figure 3.

Figure 3

Mucosal‐associated invariant T (MAIT) cells are persistently depleted in anti‐neutrophil cytoplasm autoantibody (ANCA)‐associated vasculitis (AAV) patients and disease controls. (a) Representative flow cytometric dot plots showing Vδ1, Vδ2 and Vδ3 T cells, invariant natural killer T (iNK T) cells and MAIT cells. (b–f) Frequencies of Vδ1, Vδ2, Vδ3 T cells, iNK T cells and MAIT cells in healthy controls (HC), disease controls (DC) and AAV patients in active (AP) and remission phase (RP). AAV subtypes are denoted by circle colour as granulomatosis with polyangiitis (GPA) (Inline graphic), microscopic polyangiitis (MPA) (○) and eosinophilic granulomatosis with polyangiitis (EGPA) (Inline graphic). (g–k) Absolute cell counts of Vδ1, Vδ2, Vδ3 T cells, iNK T cells and MAIT cells in DC and AAV patients in active and remission phase. Data represent median and interquartile range. One‐way analysis of variance (anova) was carried out using the non‐parametric Kruskal–Wallis test and Dunn's multiple comparison post‐test. **P < 0·01; *P < 0·05. [Colour figure can be viewed at wileyonlinelibrary.com]