Figure 2.
Effect of olaparib treatment on burn‐induced increases in heart, lung, liver and kidney MDA levels. (A) Heart, (B) lung, (C) liver and (D) kidney MDA levels are shown in sham‐control mice and in mice subjected to burn injury and in burn mice treated with olaparib (10 mg·kg−1, i.p.) once a day for 1, 6 and 20 days. Compared to non‐burn sham control, burn produced a significant increase (P < 0.05) in MDA levels in all tissues at all three time points studied. Significant effect of olaparib during burn injury in all four tissues studied is shown at 24 h (*P < 0.05). Data are shown as mean ± SEM of 10 animals for each group.