Figure 6.
Effect of olaparib treatment on burn‐induced increases in selected plasma inflammatory mediator levels. Plasma levels of IL‐2, IL‐3, IL‐4, IL‐6, IL‐10 and IL‐12(p40) are shown in sham‐control mice and in mice subjected to burn injury and in burn mice treated with olaparib (10 mg·kg−1, i.p.) once a day for 1, 6 and 20 days. Compared to non‐burn sham control, burn produced a significant increase (P < 0.05) in IL‐3 levels at 24 h and in all other mediator levels at all time points studied. Significant effect of olaparib on all six mediators studied during burn injury is shown at 24 h (*P < 0.05). Data are shown as mean ± SEM of 10 animals for each group.