Figure 5.
Effect of LY344864 on mtDNA content and mitochondrial mRNA in 6‐OHDA‐lesioned mice. Mice were subjected to bilateral intrastriatal 6‐OHDA lesions followed by 14 days of daily exposure to vehicle or LY344864 (2 mg·kg−1) beginning 7 days after lesioning. The frontal cortex, striatum, hippocampus and substantia nigra were extracted from a subset of mice from each group and analysed for mtDNA content (A) and mRNA expression of PGC1α (B) and NDUFS1 (C), two nuclear‐DNA encoded mitochondrial genes, and of ND1 (D) and COX1 (E), two mitochondrial‐DNA encoded mitochondrial genes. Data represent eight to nine mice per group and are expressed as mean ± SEM (*P < 0.05 compared to Saline + Vehicle, #P < 0.05 compared to 6‐OHDA + Vehicle).