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Olaparib protects cardiac myoblasts against acute, severe oxidative stress. (A) Experimental design. Reduction of MTT (B) and release of LDH (C) in H9c2 cells treated with 300 μM or 1 mM H2O2 in the absence or presence of 10 μM olaparib (olap). (D) Western blot analysis of PARylation , at 15 min after H2O2. ( E ) Western blot analysis of PARP1 expression, at 15min ‐24h, after H2O2. Data shown are means ± SEM. *P < 0.05, significant protective effect of olaparib; n = 5 per group.
