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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Biol Psychiatry. 2017 Jul 8;84(10):722–733. doi: 10.1016/j.biopsych.2017.06.032

Figure 3. GAT211-induced a CB1-mediated suppression of paclitaxel-induced neuropathic pain.

Figure 3

The GAT211-induced suppression of paclitaxel-induced (A) mechanical and (B) cold hypersensitivity was blocked by the CB1 receptor antagonist AM251 (5 mg/kg i.p.) but not by the CB2 antagonist AM630 (5 mg/kg i.p.). (C,D) GAT211 (20 mg/kg i.p.) did not suppress paclitaxel-induced (C) mechanical or (D) cold hypersensitivities in mice lacking CB1 receptors (CB1 KO). Data are expressed as mean ± SEM (n=5–6 per group). *P<0.05 vs. vehicle, one-way ANOVA followed by Bonferroni post hoc test. #P<0.05 vs. pre-paclitaxel baseline, repeated measures ANOVA.