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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Biol Psychiatry. 2017 Jul 8;84(10):722–733. doi: 10.1016/j.biopsych.2017.06.032

Figure 4. Dose response of GAT211 and inhibitors of endocannabinoid deactivation URB597 and JZL184 in suppressing paclitaxel-induced neuropathic pain.

Figure 4

GAT211 (0.1, 1, 2.5, 5, 10, 20, 30 mg/kg i.p.), the FAAH inhibitor URB597 (0.01, 0.1, 0.3, 1, 3, 10 mg/kg i.p.) and the MGL inhibitor JZL184 (1, 4, 8, 16, 40, 60 mg/kg i.p.) attenuated paclitaxel-induced (A) mechanical and (B) cold allodynia in a dose-dependent manner. Data are expressed as mean± SEM (n = 5-6 per group)