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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Biol Psychiatry. 2017 Jul 8;84(10):722–733. doi: 10.1016/j.biopsych.2017.06.032

Figure 5. The CB1 positive allosteric modulator GAT211 produces synergistic anti-allodynic effects with inhibitors of MGL or FAAH.

Figure 5

GAT211 synergized with (A) the MGL inhibitor JZL184 in suppressing paclitaxel-induced mechanical and (B) cold allodynia. GAT211 produced (C) synergistic antinociceptive effects with the FAAH inhibitor URB597 in suppressing paclitaxel-induced mechanical allodynia but was (D) only additive in suppressing paclitaxel-induced cold allodynia. Data are expressed as mean ED50 ± SEM (n = 6 per group) *P<0.05 vs. theoretical additive values, two-tailed t-test using Welch’s correction.