Skip to main content
. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Biol Psychiatry. 2017 Jul 8;84(10):722–733. doi: 10.1016/j.biopsych.2017.06.032

Figure 8. GAT211 increases immobility time in MGL and FAAH KO mice but not in WT mice.

Figure 8

GAT211 (20 mg/kg i.p.) increased (A) time spent immobile in the ring test in both (B) MGL KO and (C) FAAH KO mice that was reversed following co-administration with AM251 (5 mg/kg i.p.). When administered alone, GAT211 did not produce (D) motor impairment in the rotarod test, (E) antinociception in the tail-flick test, or (F) hypothermia relative to vehicle in either genotype. Responses in FAAH KO mice and MGL KO mice receiving vehicle did not differ and were pooled for statistical analysis. *P<0.05 vs. vehicle, one-tailed t-test. Mean ±SEM (n = 5-12 per group)