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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Biol Psychiatry. 2017 Jul 8;84(10):722–733. doi: 10.1016/j.biopsych.2017.06.032

Table 1.

Isobolographic analysis reveals antinociceptive synergism of combinations of GAT211 with FAAH and MGL inhibitors in a paclitaxel model of neuropathic pain

Combination with GAT211
Compound Modality Theoretical Experimental
JZL184 Mechanical 10.27 (7.52 – 13.02) 6.09 (3.94 – 9.42)*
Cold 12.04 (10.73 – 13.35) 8.17 (6.96 – 9.58)*
URB597 Mechanical 6.01 (5.08 – 7.74) 4.56 (3.38 – 6.16)*
Cold 5.57 (5.39 – 5.74) 5.27 (4.50 – 6.17)

Mean ED50 values (with 95 % confidence intervals) mg/kg i.p.

*

p < 0.05 vs. theoretical ED50