Table 1.

Definition of medication use after 365 days

Medication	ATC Code	DDD 365 days
Aspirin	B01AC06 (acetylsalicylic acid) or B01AC08 (carbasalate calcium)	180 DDD
P2Y12 inhibitor	B01AC04 (clopidogrel), B01AC22 (prasugrel) and B01AC24 (ticagrelor)	180 DDD
Statin	C10AAxx (all HMG CoA reductase inhibitors)	180 DDD
Beta-blocker	C07xxxx (all beta-blocking agents and combinations)	45 DDD
ACE inhibitor/AT2 antagonist	C09A, C09B and C09C (including combinations)	120 DDD
Vitamin K antagonist	B01AA04 (phenprocoumon) and B01AA07 (acenocoumarol)	60 DDD
Novel oral anticoagulant	B01AE07(dabigatran etexilate), B01AF01 (rivaroxaban) and B01AF02 (apixaban)	180 DDD

ACE angiotensin converting enzyme, AT2 angiotensin II ATC anatomical therapeutic chemical, DDD defined daily dose HMG CoA hydroxymethyl-glutaryl coenzyme

To increase the algorithm’s sensitivity for detecting medication usage, a threshold of 45 to 180 DDD was used