Fig. 4.

The magnitude of follicle activation directly impacts PMF reserve in ovarian grafts. a Inducing activation in ovarian follicle grafts increases the number of growing follicles in the immediate short term at the expense of the PMF population, resulting in decreased graft lifespan. This may be suitable for immediate IVF retrieval but comes at the expense of the overall fertility potential and long-term functioning of the graft. b Limiting activation at the time of transplantation reduces PMF loss thereby extending graft lifespan. It is preferable to reduce the activation that occurs with transplantation in order to maximize the fertility outcomes of the procedure