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. 2018 Jan 4;8:225. doi: 10.3389/fgene.2017.00225

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Copyright © 2018 Wang, Yang, Wang, Feng, Li, Ji and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular evolution of khdrbs genes and the origin of vertebrate tripartite brain. The evolutionary relationships of metazoan and Vertebrata are based on our analyses above and recent phylogenomic analyses. Two red bars represent the 2R WGD events happening around the origin of vertebrate linage. The yellow one indicates teleost specific WGD event. Those blue rectangles represent the process of khdrbs gene duplication and diversification. The branch lengths are not proportional to the time of diversification.