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. 2018 Jan 4;11:418. doi: 10.3389/fncel.2017.00418

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Copyright © 2018 Wang, van Woerden, Elgersma and Borst.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fewer failures in MNTB neurons of Ube3a mice. (A) Two complex waveforms from principal neuron of a C57BL/6J WT mouse recorded in the juxtacellular configuration, showing a suprathreshold eEPSP (left gray arrow), which triggers an eAP (cross), and a subthreshold eEPSP (closed circle), which is not followed by an eAP. Both eEPSPs are preceded by a prespike (black arrow heads). (B) Same recording as A, illustrating the presence of both subthreshold (filled circles) and suprathreshold events. (C) Similar as B, but from a Ube3a^E113X mouse. (D) Comparison of spontaneous failure percentages of WT and Ube3a mice from two genetic backgrounds. ^∗Indicates p < 0.05 (Mann–Whitney U test).