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. 2018 Jan 8;8:55. doi: 10.1038/s41598-017-18388-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bace1 alters leptin sensitivity and neuropeptide expression response to diet and leptin. Effects of 3-day vehicle or leptin (n = 7–14/group) on food intake and body weight change in control, Bace1 ^het and Bace1 ^KO mice on RCD (a) and HFD (b). (c) Cumulative 24-hour food intake in response to overnight fast in RCD (upper; n = 6–11 /group) and HFD (lower; n = 4–8/group) mice. (d,e) RT-qPCR of BMH Npy, Agrp, Pomc and Cart from saline or leptin-treated RCD (d) and HFD (e) control and Bace1 ^KO mice (n = 6–11 mice). Data normalized to RCD controls (dashed line in e). Agrp/Pomc and Npy/Pomc ratios for RCD (f) and HFD (g) mice. Data are means ± SEM. *P < 0.05, **P < 0.01, P < 0.001 by one-way ANOVA with Bonferroni’s multiple comparisons test (a–c), Kruskal-Wallis test (d,e) or 2-tailed unpaired Student’s t-test (f,g).