Table 2.
Dysregulation of sphingolipid metabolites in the spinal cord of SOD1G86R mice, after positive ionization, and tentative identification.
| m/z | RT | HMDB | Name | Fold change |
|---|---|---|---|---|
| 686.61 | 12.23 | HMDB32794 | As 1-1 | 0.43 |
| 624.57 | 10.41 | HMDB11765 | Ceramide(d18:0/22:0) | 0.57 |
| 638.64 | 11.5 | HMDB11767 | Ceramide(d18:0/23:0) | 0.44 |
| 564.54 | 10.25 | HMDB04948 | Ceramide(d18:1/18:1) | 0.51 |
| 594.59 | 11.59 | HMDB04951 | Ceramide(d18:1/20:0) | 0.52 |
| 622.61 | 10.41 | HMDB04952 | Ceramide(d18:1/22:0) | 0.00 |
| 620.62 | 11.5 | HMDB11775 | Ceramide(d18:1/22:1) | 0.44 |
| 636.6 | 10.82 | HMDB00950 | Ceramide(d18:1/23:0) | 0.54 |
| 678.65 | 10.68 | HMDB04955 | Ceramide(d18:1/26:0) | 0.46 |
| 730.61 | 9.56 | HMDB10704 | Ceramide-P(d18:1/24:0) | 0.54 |
| 784.66 | 10.16 | HMDB10707 | Ceramide-P(d18:1/26:1) | 0.41 |
| 784.65 | 10.92 | HMDB10707 | Ceramide-P(d18:1/26:1) | 0.49 |
| 802.65 | 10.26 | HMDB35402 | Culinariside | 0.51 |
| 812.69 | 11.09 | HMDB00140 | Glucosylceramide | 0.50 |
| 812.69 | 10.83 | HMDB00140 | Glucosylceramide | 0.61 |
| 728.61 | 9.57 | HMDB04972 | Glucosylceramide(d18:1/18:0) | 0.55 |
| 784.66 | 10.93 | HMDB04974 | Glucosylceramide(d18:1/22:0) | 0.53 |
| 810.68 | 10.84 | HMDB04975 | Glucosylceramide(d18:1/24:1) | 0.36 |
| 656.57 | 11.49 | HMDB35469 | N-(2r-hydroxydocosanoyl)-2s-amino-1,3s,4r-octadecanetriol | 0.51 |
| 712.6 | 9.56 | HMDB35472 | N-(2r-hydroxyhexacosanoyl)-2s-amino-1,3s,4r-octadecanetriol | 0.53 |
| 536.51 | 9.6 | HMDB35480 | N-[(4e,8e)-1,3-dihydroxyoctadeca-4,8-dien-2-yl]hexadecanamide | 0.54 |
| 650.65 | 14.07 | HMDB00831 | N-lignoceroylsphingosine | 0.48 |
| 650.65 | 11.08 | HMDB00831 | N-lignoceroylsphingosine | 0.49 |
| 538.53 | 10.27 | HMDB00790 | N-palmitoylsphingosine | 0.48 |
| 566.56 | 10.94 | HMDB00829 | N-stearoylsphingosine | 0.46 |
| 786.67 | 10.92 | HMDB11694 | Sphingomyelin(d16:1/24:1) | 0.52 |
| 800.69 | 11.25 | HMDB11696 | Sphingomyelin(d17:1/24:1) | 0.51 |
| 706.58 | 9.59 | HMDB10168 | Sphingomyelin(d18:0/16:0) | 0.32 |
| 781.67 | 11.25 | HMDB13468 | Sphingomyelin(d18:0/22:3) | 0.46 |
| 841.7 | 10.19 | HMDB13461 | Sphingomyelin(d18:0/26:1) | 0.45 |
| 729.61 | 9.57 | HMDB12101 | Sphingomyelin(d18:1/18:1) | 0.69 |
| 785.67 | 10.92 | HMDB12104 | Sphingomyelin(d18:1/22:1) | 0.53 |
| 844.72 | 12.1 | HMDB11698 | Sphingomyelin(d18:1/26:0) | 0.51 |
| 300.29 | 3.83 | HMDB00252 | Sphingosine | 0.55 |
Given are the dysregulated metabolites identified as sphingolipids by the Human Metabolome Database (HMDB), in the spinal cord of symptomatic SOD1G86R mice, after positive identification. m/z, mass to charge ratio; RT, retention time (min).