Table 5.
Integrated pathway analysis of spinal transcriptomic and lipidomic data of SOD1G86R mice.
| Pathway name | Source | Overlapping genes | Genes | Overlapping metabolites | Metabolites | p-value | q-value |
|---|---|---|---|---|---|---|---|
| Glycosphingolipid metabolism | EHMN | 3 | Glb1;Asah1;Sgpl1 | 4 | Ceramide (3) | 0.00047 | 0.0125 |
| Glucosylceramide (4) | |||||||
| Sphingosine (1) | |||||||
| Sphingomyelin (5) | |||||||
| Sphingolipid metabolism | KEGG | 4 | Glb1; Asah1; Cerk; Sgpl1 | 4 | Ceramide (3) | 0.0001 | 0.00062 |
| Glucosylceramide (4) | |||||||
| Sphingosine (1) | |||||||
| Sphingomyelin (5) | |||||||
| Retrograde endocannabinoid signaling | KEGG | 6 | Gabrq;Gngt2;Adcy7; Plcb2; Gng8;Itpr2 | 3 | Anandamide (1) | 0.00057 | 0.0141 |
| Phosphatidylethanolamine (4) | |||||||
| Phosphatidylcholine (17) | |||||||
| Sphingolipid signaling pathway | KEGG | 11 | Ctsd; Asah1; Pik3cg; Sgpl1; Plcb2; Gab2; Rac2; Rac3; S1pr3; Tnfrsf1a; Fcer1g | 3 | Ceramide (3) | 0.0001 | 0.00297 |
| Sphingosine (1) | |||||||
| Sphingomyelin (5) |
Given are the metabolic pathways identified as significantly dysregulated in a joint inter-omic analysis performed with IMPaLA. The analysis was performed with the 751 genes and 293 lipid metabolites significantly dysregulated. The table shows the pathways, the source of the database, number and identity of genes and metabolites dysregulated per pathway, and p-value and q-value (false discovery rate) for each pathway.